Onder andere met: Wesley Snipes (Blade), Kris Kristofferson (Whistler), Dominic Purcell (Drake), Jessica Biel (Abigail Whistler), Ryan Reynolds (Hannibal King), Parker Posey (Danica Talos), Mark Berry (Chief Martin Vreede), John Michael Higgins (Dr. Edgar Vance), Callum Keith Rennie (Asher Talos), Paul Levesque (Jarko Grimwood), Paul Anthony (Wolfe), Françoise Yip (Virago), Michael Anthony Rawlins (Wilson Hale), James Remar (Ray Cumberland), Natasha Lyonne (Sommerfield), Ginger Broatch (Zoe), Patton Oswalt (Hedges), Ron Selmour (Dex), Christopher Heyerdahl (Caulder), Eric Bogosian (Bentley Tittle), Scott Heindl (Gedge), Erica Cerra (Goth)