Onder andere met: Ben Affleck (Nick Dunne), Rosamund Pike (Amy Elliott-Dunne), Patrick Harris (Desi Collings), Tyler Perry (Tanner Bolt), Carrie Coon (Margo), Kim Dickens (Detective Rhonda Boney), Patrick Fugit (Officer James Gilpin), Casey Wilson (Noelle Hawthorne), Missi Pyle (Ellen Abbott), Sela Ward (Sharon Schieber), Emily Ratajkowski (Andie), Lisa Banes (Marybeth Elliott, Amay’s mother), David Clennon (Rand Elliott, Amy's father)