Onder andere met: Marlon Brando (Dr. Moreau), Val Kilmer (Montgomery), David Thewlis (Douglas), Faizura Balk (Aissa), Ron Perlman (Sayer of the Law), Daniel Rigney (Hyena-Swine), Temuera Morrison (Azazello), Nelson de la Rosa (Majai, a miniature version of Dr. Moreau), Peter Elliott (Assassimon), Mark Dacascos (Lo-Mai), Marco Hofschneider (M'Ling), Miguel López (Waggdi), William Hootkins (Kiril)