Onder andere met: Nathan Fillion (Captain Malcolm 'Mal' Reynolds), Gina Torres (Zoë Washburne), Alan Tudyk (Hoban 'Wash' Washburne), Morena Baccarin (Inara Serra), Adam Baldwin (Jayne Cobb), Jewel Staite (Kaylee Frye), Sean Maher (Dr. Simon Tam), Summer Glau (River Tam), Ron Glass (Shepherd Book), Christina Hendricks (Saffron), Mark Sheppard (Badger), Michael Fairman (Adelai Niska), Richard Brooks (Jubal Early), Isabella Hofmann (Regan Tam), Melinda Clarke (Nandi)