Onder andere met: Will Ferrell (Ron Burgundy), Steve Carell (Brick Tamland), Paul Rudd (Brian Fantana), David Koechner (Champ Kind), Christina Applegate (Veronica Corningstone), Dylan Baker (Freddie Shapp), Meagan Good (Linda Jackson), Judah Nelson (Walter Burgundy), James Marsden (Jack Lime), Greg Kinnear (Gary), Josh Lawson (Kench Allenby), Kristen Wiig (Chani Lastnamé), Fred Willard (Ed Harken), Chris Parnell (Garth), Harrison Ford (Mack Tannen), Jennifer Gullick (Diane Yahwea), Daisy Pareja (Lupita)